Epithalon

$456.00 USD

Epithalon is a synthetic tetrapeptide extensively studied in longevity and cellular aging research. Modeled after a natural peptide secreted by the pineal gland, Epithalon has gained scientific attention for its potential to support telomere length maintenance, circadian rhythm regulation, and oxidative balance at the cellular level.

In laboratory studies, Epithalon has been observed to influence melatonin secretion and activate telomerase in somatic cells—two processes associated with aging and cellular homeostasis. These properties make it a candidate of interest in experimental research focused on lifespan extension, DNA repair, and age-related biological markers.

Often explored in models of neurodegeneration, immune regulation, and oxidative stress, Epithalon may help researchers better understand peptide-based mechanisms in healthy aging. Its simplicity, stability, and ability to modulate molecular signaling make it an essential component in the field of biogerontology and regenerative science.

Epithalon, also known as Epitalon (Ala-Glu-Asp-Gly), is a pineal-derived synthetic peptide that has been the subject of extensive research in cellular aging, telomere science, and regulatory peptide biology. A seminal in vitro study demonstrated that Epithalon induces significant telomerase activity and telomere elongation in human somatic cells. Treated fibroblasts exhibited activation of the telomerase catalytic subunit and extended telomere length beyond the standard Hayflick limit, indicating potential for extended cellular lifespan (Alzheimer's Drug Discovery Foundation, Revolution Health & Wellness, Ingenta Connect, PubMed). Research in animal models and human cohorts has revealed that Epithalon may support pineal gland function and melatonin production, which frequently declines with age. In aged primates and elderly participants, treatment with this peptide was associated with normalized melatonin synthesis and improved circadian rhythm regulation (ResearchGate, PubMed). Additional studies have explored its antioxidant and immune-supportive effects. In aging oocyte models, Epithalon increased antioxidant enzyme activity (such as superoxide dismutase), reduced reactive oxygen species (ROS), and preserved cellular morphology, suggesting protective effects against oxidative stress in aging cells (Aging-US). Epithalon’s compact tetrapeptide structure and chemical stability make it well-suited for laboratory investigations across in vitro and in vivo systems, including research on DNA stability, immune aging, sleep modulation, and cellular senescence pathways.

Research & References:

V. Khavinson et al., “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells,” Bull Exp Biol Med. 2003. (PubMed)
O.V. Korkushko et al., “Epithalamin increases pineal melatonin secretion in aged rats and elderly humans,” Bull Exp Biol Med. and related follow‑up studies. (ResearchGate)
Aging‑cell/oocyte model study: Epithalon reduced oxidative stress and improved oocyte integrity, including increased SOD activity and reduced ROS in aging models (Aging-US)