{"product_id":"pda","title":"PDA (Pentadeca Arginate)","description":"\u003cp data-start=\"1167\" data-end=\"1579\"\u003ePDA (Pentadeca Arginate) is a poly-arginine peptide composed of approximately fifteen arginine residues, placing it within a class of molecules commonly referred to as \u003cstrong data-start=\"1335\" data-end=\"1371\"\u003ecell-penetrating peptides (CPPs)\u003c\/strong\u003e. These peptides are characterized by their high cationic charge density, which allows them to interact with negatively charged components of the cell membrane, including phospholipids and glycosaminoglycans.\u003c\/p\u003e\n\u003cp data-start=\"1581\" data-end=\"2082\"\u003eOne of the primary areas of research involving PDA is its role in \u003cstrong data-start=\"1647\" data-end=\"1693\"\u003ecellular uptake and intracellular delivery\u003c\/strong\u003e. Studies on poly-arginine peptides (such as R8, R9, and longer arginine chains) have demonstrated their ability to translocate across cellular membranes via mechanisms including endocytosis and direct membrane penetration. PDA, with its extended arginine chain, is of interest for investigating enhanced delivery efficiency of peptides, nucleic acids, and other macromolecules into cells.\u003c\/p\u003e\n\u003cp data-start=\"2084\" data-end=\"2578\"\u003eIn addition to its transport capabilities, PDA is studied in relation to \u003cstrong data-start=\"2157\" data-end=\"2197\"\u003enitric oxide (NO) signaling pathways\u003c\/strong\u003e. Arginine is a known precursor to nitric oxide, a key signaling molecule involved in vascular tone, endothelial function, and cellular communication. While PDA itself is not directly converted into nitric oxide in the same manner as free L-arginine, its high arginine content makes it relevant in research exploring arginine-associated signaling environments and vascular biology.\u003c\/p\u003e\n\u003cp data-start=\"2580\" data-end=\"3006\"\u003ePDA is also examined for its interaction with \u003cstrong data-start=\"2626\" data-end=\"2662\"\u003ecell membranes and biointerfaces\u003c\/strong\u003e. Its strong electrostatic interactions allow it to bind to membrane surfaces, making it useful in studies of membrane permeability, peptide–lipid interactions, and drug delivery systems. These properties are particularly relevant in the development of advanced delivery platforms, including nanoparticle conjugation and peptide-based carriers.\u003c\/p\u003e\n\u003cp data-start=\"3008\" data-end=\"3313\"\u003eIn tissue and vascular research, arginine-rich peptides have been evaluated for their ability to influence endothelial cell behavior, including cellular adhesion, migration, and response to oxidative stress. PDA’s structure makes it suitable for studying these processes in controlled experimental models.\u003c\/p\u003e\n\u003cp data-start=\"3315\" data-end=\"3540\"\u003eDue to its stability and high solubility, PDA is also used in formulation research, where it may be combined with other peptides or biomolecules to enhance delivery efficiency and bioavailability in vitro and ex vivo systems.\u003c\/p\u003e","brand":"Chroma23® Peptides","offers":[{"title":"10","offer_id":47968873480427,"sku":null,"price":196.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0791\/1332\/2731\/files\/PDA-Chroma-VIal.jpg?v=1774982912","url":"https:\/\/shop.chroma23peptides.com\/products\/pda","provider":"Chroma23® Peptides","version":"1.0","type":"link"}